We thereby bring an additional level of complexity in the highly complex role played by PGE2 in colon cancer progression.
The state regulation does not simplify the problem but instead imports an additional level of complexity.
Crusoe microprocessors, which are made by Transmeta, have an additional level of complexity: special software that translates all commands.
An additional level of complexity is added by the frequent presence of multiple response elements in gene promoter regions.
Biological systems have an additional level of complexity compared to other chemical systems because of the effects of metabolic regulation, a defining feature of biosystems.
An additional level of complexity is provided by the fact diacylglycerol (DAG) signals can be transduced by phorbol ester receptors other than PKC.
The sensitivity of inverse agonists and protean agonists to receptor desensitization implies an additional level of complexity in structure activity relationships.
From a physiological point of view, this modulation can be seen as an additional level of complexity in the cell signaling process.
We have recently discovered an allosteric switch in Ras, bringing an additional level of complexity to this GTPase whose mutants are involved in nearly 30% of cancers.
Intact plants have an additional level of complexity since they are living systems which critically depend on transport and signalling processes between and within tissues and organs.
The complexity of the cancer biology being the result of so many different interactive mechanisms whether driving or not the process of cancer cells is an additional level of complexity to approach more inclusive clinical trial access.
