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The dipeptidomimics interacted only with S1′ and S2′ subsites, whereas the tripeptidomemics had additional interaction with S1 subsite, which accounted for their significant ACE inhibition potencies.
Instead, an additional interaction with Fcγ receptor expressing cells was needed.
The assumed mechanism involves an additional interaction with an otherwise unseen field, called the Higgs field, that pervades all space.
The sulfonate moiety provides additional interaction with Lys15′ and a water-mediated hydrogen bond with Thr119′.
This provides an additional interaction with the enzyme and may overcome the problem of resistance encountered with these drugs.
This difficulty is the impetus for additional interaction with the court, as jurors must often call on legal assistance when drafting their verdicts.
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Pat1 appears to have additional interactions with the Lsm1-7 complex as the middle domain of Pat1 can interact with the Lsm1-7 complex.
Computational analysis suggested structural alterations that could provide additional interactions with RT and thus improve inhibitory potency.
These interactions can be modulated by additional interactions with residues adjacent to the turn at positions i + 4 and i + 6.
TAK779 binds to CCR5 in the cavity formed by helices 1, 2, 3, and 7 with additional interactions with helices 5 and 6.
Modeling of these inhibitors revealed the same overall binding mode with the enzyme as triclosan, but the B-ring modifications have additional interactions with the strongly conserved Asn130.
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