Exact(4)
In both cases, an association between the additional imbalance and the clinical phenotype was deemed unlikely.
This method could however produce biased results if there is an additional imbalance in background variables which are not stated in the model (e.g. smoking or other confounders).
As a consequence of the high bone turnover, which would release Pb from its inactive state in bone hydroxyapatite crystals, an additional imbalance of bone resorption over formation would occur from Pb's preferential toxic effects on osteoblasts.
We made use of this methodological resource, with the exact intention of under-representing samples from centres with a smaller population, since otherwise it would be more costly in resources and time to reach those centres, which would then lead to a different weighting of results to take this additional imbalance into account.
Similar(56)
Notably, there was an increase in the overall detection rate of genomic imbalances with CMA V5 (8.9%) relative to CMA V4 (7.6%) (Table 1), indicating that the increase in coverage of genomic disorder regions in the array enables additional imbalances to be identified in these screening tests even in the absence of case selection on the basis of normal cytogenetic studies.
Some additional imbalances which occured only in few entities at high levels are listed in Table 3.
Workforce mobility can create additional imbalances that require better workforce planning, attention to issues of pay and other rewards and improved overall management of the workforce [ 2].
Lastly, there may be additional imbalances between the two study groups that could have increased the severity of VAP (for example, corticosteroid therapy, chronic obstructive pulmonary disease) that were not included in our analysis.
The additional genomic imbalance detected by CMA may explain the clinical findings including growth retardation and dysmorphic features, which were inconsistent with 47,XYY karyotype in this patient.
A genome-wide array-CGH analysis did not show any additional genomic imbalance, with the exception of known copy number variations already reported on the Database of Genomic Variants (http://projects.tcag.ca/variation/).tcag.ca/variation/
While it is possible that the D494G mutation does not contribute to the ethanol tolerance phenotype of strain E50C, a more likely explanation is that the additional redox imbalance(s) caused by deletion of hydG prevent the D494G mutation from rebalancing metabolism.
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