The phrase "additional difficulty in the" is correct and usable in written English.
It can be used when discussing challenges or obstacles that are being added to a situation or task.
Example: "The new regulations have created additional difficulty in the implementation of the project."
Alternatives: "extra challenge in the" or "further complication in the".
An additional difficulty in the development of QSAR models is the fact that some regression methods have parameters that need to be optimised to obtain the best performance for a particular problem.
The different lapses of time between surveys, 3 months between the first and the second and between the third and the fourth, and 6 months between the second and the third, introduces an additional difficulty in the estimations.
Another factor that introduces an additional difficulty in the analysis of Snail1 RNA is the existence of a human retrogene with a similar sequence to Snail1 that may interfere with the reverse transcription PCR analysis of Snail1 RNA [21].
This list of key genes was not duplicative between the higher accuracy weighting schemes leading to additional difficulty in the interpretation process.
An additional difficulty in the decision to administer adjuvant treatment may be the new tumour-node-metastasis (TNM) classification [13,14].
An additional difficulty in the interpretation of associations between tobramycin leakage to clinical variables is the lag time between renal dysfunction and the rise of tobramycin.
Faced with a constant pressure to cut costs, increase productivity and keep patients happy, plus the additional difficulty in this case of discussing prognosis with a terminal cancer patient, many of the doctors no doubt experienced significant levels of stress.
A strong 8 9 MHz noise from the RF plasma heating generators forms additional difficulties in the diagnostic signal measurements in the U-3M and U-2M torsatrons compared with other stellarators and tokamaks.
In the Fischer Tropsch synthesis, the multitude of reaction products as well as the large number different reaction pathways does result in additional difficulties in the search for the active site/ensemble.
