In the current setting additional concerns regarding spatial selection bias may be raised when excluding nongeocoded data due to the fact that geocoding success, more precisely the prevalence of nongeocodes, is often not geographically neutral [26], [27].
The recent role out of antiretroviral therapies and new antimalarials, such as artemisinin combination therapies, raise additional concerns regarding possible synergistic and antagonistic effects on efficacy and toxicity.
Last year saw the publication of several articles related to cardiac arrest that raised additional concerns regarding the utility of IV medication administration in ALS algorithms.
Women did not mention additional concerns regarding maternity services, contrary to the Swedish women that participated in the study by Georgsson Öhman et al. [ 16].
Recent studies have shown that reprogramming itself can induce both genetic and epigenetic abnormalities, fostering additional concerns regarding the safety of iPSCs in clinical use.
Additionally, in the present study, there were relatively few non-targets as compared with targets in the Not-X CPT (48 vs. 432), potentially introducing additional concerns regarding the sensitivity and precision of this contrast.
