Whilst the synovial membrane represents the epicentre of the immune-inflammatory process, there is growing evidence indicating the potential involvement of additional anatomical compartments, such as the lung, bone marrow, and secondary lymphoid tissues.
In addition, SLs may be incorporated into other intracellular compartments, such as mitochondria or autophagosomes.
However, RISC proteins can associate with membrane compartments such as the Golgi and endoplasmic reticulum4.
In particular, we are interested in understanding how membrane-free cellular compartments such as RNA granules form and function.
Fast-GCaMP6f variants should be useful for tracking action potentials closely spaced in time, and for following neural activity in fast-changing compartments, such as axons and dendrites.
DNA sequences that encode signal peptides targeting intracellular compartments, such as the cytoplasm (cyto), nucleus (nuc), mitochondria (mito), or peroxisomes (perox) were fused on demand.
The regulation of intracellular ROS level depends on endogenous enzymatic systems, located in different cellular compartments, such as catalase, superoxide dismutases and peroxiredoxins, as well as non-enzymatic systems, such as glutathione (GSH), ascorbic acid and α-tocopherol7,8.
Most of the statistically significant enriched compartment pairs are those paired with same compartment or adjacent compartments such as ER and Golgi (Figure 5).
Algae and plant cells have subcellular compartments such as chloroplast, mitochondria, and cytoplasm.
