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CCD is afirst-order (2N) designs augmented by additional centre and axial points.
The additional centre was the Wolfson Molecular Imaging Centre Manchester, UK (WMIC).
CCD are first-order (2K) designs augmented by additional centre and axial points to allow estimation of the tuning parameters of a second-order model.
Plasma and tumour samples were analysed from six centres, five participating centres in the IMI QuIC-ConCePT Consortium and one additional centre.
Taking into account the expected 5% attrition, one additional centre is needed.
A sensitivity analysis (logistic regression with an additional centre variable) led to only marginal changes of our findings.
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Those were moments during the match when Fernandinho dropped back from midfield to play in between John Stones and Aleksandar Kolarov as an additional centre-half.
Mindful of the fitness concerns over the captain Ledley King, who was appearing for the first time in a month, he had sent on Younes Kaboul as an additional centre-half.
Médecins Sans Frontières (MSF) opened a clinic last week in one of the hardest-hit areas of the city and Abubakar said health officials are considering opening two additional centres in the coming weeks.
Then, the assay has been further validated on a cohort of 8 different mutants and 4 non mutated DNA in 2 additional centres, of whom one functioned in a blind manner.
With inclusion of additional centres, FORBOW is likely to become a multi-centre study.
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