In addition to these common features, additional abnormalities were detected in 11 of 37 cells (Supplementary Fig. S1C and D).
Therefore, additional abnormalities must co-exist in addition to the loss of PTEN for colon tumor cells to become fully invasive and metastatic.
However, due to cytogenetic heterogeneity, the additive prognostic impact of distinct single additional abnormalities remains obscure as yet (Table 4).
A BRCA pathway deficit causes an underlying deficiency in error-free repair that increases the number of abnormal cells and adds further to the chances for additional abnormalities.
Moderate intoxication includes additional abnormalities such as hyperactive bowel sounds, high blood pressure and hyperthermia; a temperature as high as 40 °C.
Most of the additional abnormalities were too small to be detected by karyotypes.
The other 16 patients achieved a symptom-limited test below their predicted peak VO2, and also had additional abnormalities.
Moreover, no additional abnormalities are observed in mice lacking Map3k1 and a single copy of Map3k4, suggesting that no genetic interaction occurs between these loci during sex determination.
Two additional abnormalities related to peritoneal macrophages and BAT were observed in a mouse background-dependent manner, suggesting involvement of modifying genes in different mouse backgrounds.
Additional abnormalities seen in Vav1-deficient thymocytes include decreased expression of TCR-β and a marked reduction in expression of CD5, an activation marker that reflects strength of in vivo signaling of DP cells.
