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In addition to the variant residues, our data indicate that a (H/K/N xx(S/T)(S/N K/R KK motif located immediately prior to the dimerization region is also used by class V AtFYVE domains to recognize either headgroup (Fig. 5B).
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Additionally, we calculated the AUC under an ROC curve in which a model including all variants (additive) is compared with a model including a two-way interaction term in addition to the variants (interaction).
In addition to the variants validated to determine specificity, validation was also targeted to several hundred substitutions involved in regions of hypermutation and dinucleotides (Table S1 B).
In addition to the variants, their genomic locations and corresponding genetic consequences, a number of trait association data (23) are also exposed.
One could argue that in addition to the variants within Adamts16, there may be other variants within inter-genic or intra-genic regions of the critical QTL interval that contribute to the QTL effect.
GLI3 has a large number of variants in addition to the simulated variant.
In addition to the rare variant in DNAH5, a single rare missense variant in DYX1C1 (c.988C > T; p.R330W) was found in WES data.
It would be interesting to analyze patients with retinal dystrophy who carry mutations in other IRD-associated genes in addition to the p.A615T variant in HGSNAT, to determine whether this variant has an additional effect on the phenotype.
In addition to the SENNA variant we used for generating the PASs (SENNA*) we also tested an even faster SENNA variant downloadable from the NEC labs site (SENNA 1.0 web).
In order to search for additional instances, we analysed published GWAS http://www.genome.gov/26525384 and, in addition to the aforementioned variant in PTPN22, we identified rs744166 in STAT3 and rs2201841 in IL23R (Table 1).
The iPhone 6S and 6S Plus will also be available in a new rose-gold colour, the pink gold will be sold in addition to the gold variant, which was first introduced with the iPhone 5S in 2013, primarily to appeal to the Chinese market.
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