In addition to the regulators discussed above, several other factors were bivalent in different combinations of the cell types (Additional file 1: Figure S4).
In addition to the regulators for G1/S transition, Aurora A and anaphase-promoting complex/cyclosome (APC/C), both of which mainly function at M phase, are reported to regulate neuronal migration and axon/dendrite formation (Konishi et al. 2004; Kim et al. 2009; Mori et al. 2009; Takitoh et al. 2012).
In addition to the global regulators PhoP-PhoQ and PmrA-PmrB, recently regulation of the Kdo2-lipid A modification enzymes by small RNAs (sRNAs) and small peptides in certain bacteria has also been reported.
In addition to the secondary regulators found in gene clusters 1 and 2, additional regulatory proteins are included in clade-specific SigB regulons (see below), and may modulate the control of gene expression by SigB, confounding the results of in vitro experiments.
In addition to the transcriptional regulator Aire, epigenetic mechanisms and post-transcriptional expression control have been implicated [ 8, 13].
BMP-2 has been shown to induce several other transcription factors that promote differentiation such as Runx2/Cbfa1, Sp7/osterix and ZNF450 in addition to the negative regulator Id1 [ 7, 28- 30].
Interestingly, in addition to the positive regulator of cell cycle progression, CCND1, a crucial cyclin-dependent kinase inhibitor, CDKN1A (also known as P21), was also induced after CRY2 knockdown.
In addition to the classic transcriptional regulators, compelling evidence indicates that microRNAs (miRNAs) also regulate energy metabolism and liver functions (Fernandez-Hernando et al, 2011, 2013).
The only organic supplements required for optimum differentiation were thiamine and nicotinic acid, in addition to the plant growth regulators BAP and NAA and sucrose as a carbon source.
In addition to the tougher rules, regulators cite the increase in the number of inspectors, from 55 to 92, as part of the safety push.
In addition to the core components, regulators such as Susi [ 14], Steppke [ 15] and Lnk [ 16, 17] modulate IIS activity.
