Such tRNAs would require editing in order to create the standard Watson Crick base pairing necessary for functional mature tRNAs, thus a second RNA editing system (e.g., mitochondrial 5′-tRNA editing; Jackman et al. 2012) would probably be required in addition to the mRNA editing system (see above).
In addition to the appended editing domains and N- or C-terminal extensions which provide additional tRNA binding, we also identified free standing editing domains of AlaRS/ThrRS, two ProRS deacylases and two D-tyrosine deacylases (DTD).
In L. major, in addition to the tethered editing domains in the AlaRS (LmjF.22.1540) and ThrRS (LmjF.35.1410), a freestanding tRNA_SAD (LmjF.15.0690) domain was also found.
While the smaller size of BpsuCas9 is of potential utility for more efficient use of biological shuttle vectors during transformations and viral transductions, the unique sequence of BpsuCas9 might allow for some alternative uses of these endonucleases, for example and in addition to the genome editing and genome engineering.
In addition to transcriptional regulation, we confirmed the editing of known ADAR targets in rat, and discovered that, in addition to the known edited miRNAs, mir-377 is edited in rat brains.
Thus, in addition to the aaRS, the editing domains (both cis- and trans-) are also novel drug targets.
In addition to these editing of miRNAs, 4 SNPs in miRNAs were also identified in our analysis.
In addition to the grace of its editing, there are moments of tremendous humour.
In C. gronovii, in addition to the rpl20-103 and the rps2-83 editing sites, two potential editing sites remain unedited at position 72 in psbE and position 2 in petL, which are edited in C. reflexa or already have the conserved amino acid encoded at the DNA level.
In addition to The New Masses, Betty edited long hours for Latin America Today.
