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In addition to the alteration of the left BA38 as reported by this study, previous interictal studies usually found volume and functional alteration in brain stem, thalamus, anterior cingulate cortex, insula, prefrontal cortex, etc., indicating the involvement of multiple brain regions in migraine processing network [5, 6].
RIM1 knockout mice show disturbance in the areas of long-term memory and the associative learning deficit in fear conditioning [46], in addition to the alteration of pre-synaptic long-term potentiation (LTP) [17], although RIM1 knockout mice have no consolidation or anxiety-related behavior phenotypes.
In addition to the alteration of kidney functions, cisplatin treatment caused a significant decrease in the body weight of rats within 5 days (Table 1).
In addition to the alteration of markers of androgenic action, the endocrine feedback loop (mainly the hypothalamic– pituitary target organ axis) could also be affected by BPA, showing no compensatory mechanisms of increased LH or FSH.
In addition to the alteration in β-catenin labeling, a reduced expression of the transmembrane protein E-cadherin was observed at the cell membrane of ileo-caecal epithelia after 45 days post-infection.
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In addition to the alterations on the core Hippo pathway, a number of other molecular pathways commonly altered in human carcinogenesis have the ability to cross talk with the Hippo pathway (reviewed by Irvine [33]).
In addition to the alterations in signal transduction and disturbances in Ca2+ homeostasis, there are structural changes in myofilaments, disorganization of the cytoskeletal framework and increased collagen synthesis.
In addition to the alterations in subset frequencies, T cells in rheumatoid patients are hyporesponsive to stimulation through the T-cell receptor (TCR).
In addition to the alterations in HER receptors, mutations in genes involved in the signaling pathways activated by these receptors are also correlated with the carcinogenesis process and failure of therapeutic response to HER inhibitors [ 14].
In addition to the alterations in leptin function inherent to the ob/ob mouse, disturbances in intestinal monosaccharide transport appears to also play a role in developing obesity and the diabetic state, via increased fructose absorption, 6 which is mediated specifically via GLUT transporters.
In addition to the alterations of upstream activators, genetic amplification of downstream effectors, such as eukaryotic initiation factors 4E (eIF4E), p70 ribosomal protein S6 kinand1 (S6K1), and eukaryotic translation initiation factor 4E binding protein 1 (4E-BP1), also result in enhanced mTOR activation, which contributes to its hyperactivity in human cancers [7], [8].
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