Our identification of differential methylation in genes known to be involved in the response to tobacco-related compounds, in addition to a novel gene, demonstrates the value of using this approach to elucidate the epigenetic effects of in utero exposures.
In addition to a previous report that demonstrated that overexpression of PLK1 had been observed in the early stage of pancreas cancer, our data suggested that PLK1 might be a promising target for the treatment of pancreas cancer.
In addition to a 360 bp product, demonstrating PTM expression, a 550 bp trans-spliced product was detected after injection with LVSyn-TauPTM6 or LVUb-TauPTM6 (Fig. 6B).
In addition to demonstrating a role for AF-6, previous studies had demonstrated a role for the Rap1 activator PDZ-GEF2 in both lung cancer cell adhesion [ 35] and colorectal carcinoma cell migration [ 27].
In addition to demonstrating a "catch-and-pass" reaction mechanism in a small molecule kinase, we demonstrate that binding of our analogs to the substrate capture site inhibits PPIP5K2.
Electrochemical testing showed that the N-CNFs grown from Fe exhibited a notable activity for the oxygen reduction in both acidic and alkaline electrolyte, in addition to demonstrating a high durability with a well-preserved catalytic activity after 1600 cycles in O2-saturated 0.5 M H2SO4.
In addition to demonstrating a need for capacity building in clinical care for sexual assault survivors, the study also demonstrated the effectiveness of the IRC CCSAS training tool in improving HCPs' attitudes, knowledge, confidence, and practices in diverse humanitarian settings globally.
In addition to demonstrating a new methodological tool, our work therefore makes an important empirical contribution regarding future U.S. shale oil supply.
In addition to demonstrating a novel approach to engineer salt-tolerant crops, the results provide the first glimpse of a previously unknown mechanism used by plants to regulate gene expression in response to salt stress.
This result, in addition to demonstrating a more sophisticated method to study aspects of wound healing processes, strongly suggests that even in the presence of adhesive cell cell interactions, the cues provided by the underlying substratum topography continue to exercise substantial influence on cell behavior.
