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The addition of loop scores combining the effects of both location and size as a new criterion for the prediction of MREs and their cognate miRNAs to FindTar, a computational algorithm developed in our lab, decreased the false positive rates and increased the accuracy of MRE prediction significantly.
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Antihypertensive treatment was intensified including addition of loop-diuretic and hydration.
In addition, movements of loop 1 produced when the tRNAi enters the PIN state would disrupt some interactions between this loop and rRNA shown previously to be important for tight binding of eIF1 to the 40S subunit (Martin-Marcos et al., 2013).
Since the central loop of miRNA MRE appeared to be important for miRNA-mediated gene regulation, addition of a loop score as a criterion for MRE prediction should improve the results.
Molecular dynamics simulation study showed that the addition of foreign loop into GFP did not have a negative influence on the conformation stability of GFP structure, but the GFP variant with the foreign loop sequence was completely misfolded in real folding conditions.
Thus, we implement the addition of a loop counter to compensate for these rare cases.
It was further determined that the addition of a loop score combining both location and size as a new criterion for predicting MREs and their cognate miRNAs significantly decreased the false positive rates and increased the specificity of MRE prediction.
This is represented graphically in the pair-HMM by the addition of a loop with non-zero weight ε from the match state to itself.
The visual nature of his art has changed with his ideas about scale, typeface and punctuation, and the addition of balletic loops, like the one that suggests the trajectory of a leaping fish in "Taken to as Deep as the Sea Can Be".
At some point with addition of multiple loops, the borehole resistance model effectively transitions to a central pipe equivalent diameter, d eq, with a grout gap defined by: {R}_{mathrm{b}} = {R}_{mathrm{p}}/2{N}_{mathrm{L}} + mathrm{L}mathrm{N}left(D/{d}_{mathrm{eq}}right)/left(2pi {k}_{mathrm{g}}right), (14 where (Z + d) ≤ d eq ≤ (2N L − 2 d for N L = 2, 3, or (2N L − 1 d for N L = 2.
With the addition of closed-loop optogenetic feedback, excess inhibition reduces spike activity either during EC-dominant or CA3-dominant periods of the theta cycle.
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