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Most of the evidence for the role of complement in preventing systemic damage comes from experimental data obtained in these studies in which the addition of complement inhibitors blocks or reduces damage [49].
Examples of this variation include the addition of complement or reporting sera dilutions before or after the addition of virus.
Additionally, since microglia cells require complement system activation to exert their function on synaptic pruning, the addition of complement system proteins might be required.
We have found that crosslinking does enhance the degree of apoptosis after rituximab treatment in our two cell lines, while addition of complement has little effect (data not shown).
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The addition of complement-containing plasma and interleukin-2 increased the cytotoxic effect induced by both mAbs.
In addition, inhibition of complement activation may be a potential target for prophylactic and therapeutic interventions.
In addition, expression of complement receptor 2 (CR2/CD21) and complement receptor 1 (CR1/CD35), molecules that are expressed on B lymphocytes and T lymphocytes as well as follicular dendritic cells and are known links for innate and adaptive immunity, is required to develop CIA.
The extracorporeal circulation (ECC) causes changes in cellular and cytokine pattern in addition to activation of complement system.
In addition, the activation of complement factors and secondary mediators of inflammation such as cytokines and chemokines has been demonstrated in serum from AMD patients [ 3, 11– 13].
The addition of Tyson Chandler to complement Anthony and Amar'e Stoudemire would appear to give the Knicks perhaps the most formidable frontcourt in the N.B.A.
One strategy to enhance outcomes is the addition of pharmacotherapy to complement behavioral treatment, but to date no efficacious medications targeting cannabis use disorders in adults through large, randomized controlled trials have been identified.
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