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We showed that precision can be improved through the addition of cluster design-related terms.
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Without the addition of clusters, reduction was not observed as seen from the retention of the color.
In addition, members of Cluster 2 the strongest cluster are also in a significantly higher grade.
Qin et al. used natural selection to explain the additions of clustered nodes [ 12].
Their analytic results provide powerful evidence for functional constraints as the driving force of the additions of clustered interacting nodes.
Another evidence for the additions of clustered interacting nodes comes from the analyses of yeast protein complexes [ 57].
Our results suggest functional constraints may be the underlying driving force for such additions of clustered interacting nodes.
Also, the 0.4 threshold included both expansions and additions of clusters, such as the expansion of and anti-histamine cluster to include additional anti-histamines, and the addition of a tumorigenesis gene cluster.
In 2003, based on the finding that proteins of similar phylogenetic profiles tend to interact with each other [ 12], Qin et al. first presented the hypothesis that the evolution of PINs has undergone the additions of clustered nodes.
Based on the finding that proteins of similar phylogenetic profiles tend to interact with each other, Qin et al. for the first time presented the hypothesis that the evolution of PINs has undergone the additions of clustered nodes [ 12].
Our findings provide novel evidence for the hypothesis of the additions of clustered interacting nodes and point out network motifs, especially the motifs with the dense topology and specific function may play important roles during this process.
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