Sentence examples for addition of a functionally from inspiring English sources

The overabundance of mutations in the PAS domain, not present in KCNQ1, highlights its functional importance and suggests that that the addition of a functionally important domain in a protein can increase susceptibility to disease.

The addition of a functionally blocking prostasin antibody to the ibuprofen-treated cells however, prevented the TEER increase and counteracted IBU's effect (Fig.  4a).

We contrasted a regular physical mixing treatment (upper 2 cm reworked with a sediment stirrer) with the addition of two functionally different macrobenthos species (a bioturbator and a bio-irrigator) in single-species treatments.

Upon addition of Dox, functionally relevant expression of p16 in MiaPaca-2-TREx-p16 was reproducibly obtained as judged from the ability to downmodulate pRB (Fang et al, 1998) and to reduce colony formation in soft agar (Plath et al, 2000), but did not block proliferation of MiaPaca-2 cells.

Upon addition of Dox, functionally relevant expression of wt TP53 in DanG-TREx-TP53 and MiaPaCa-2-TREx-TP53 was reproducibly obtained, as judged from the ability to inhibit G1 cell cycle progression by upregulation of p21WAF1/CIP1 (Vikhanskaya et al, 2007).

Furthermore, osteoclasts generated after the addition of sRANKL were functionally more aggressive, exhibiting a considerable increase in the extent of resorbing activity in patients with acute Charcot's osteoarthropathy.

The addition of a BODIPY 630/650 fluorophore resulted in a series of functionally active molecules.

This paper introduces a novel configuration, namely double functionally graded (DFG) structure, which comprises of a functionally graded honeycomb filler in a functionally graded thickness (FGT) tube.

In addition, sequence alignment of Hs II, demonstrated that this region was evolutionarily conserved between human, mouse, cow, dog and oppossum, suggesting the possibility of a functionally important role for this DNA element (Figure S1).

In addition, products of genes functionally annotated as "translation regulator activity" (GO 0045182) (8 singletons) and "transcription regulator activity" (GO 0030528) (2 contigs, 15 singletons) were also identified, which encompassed transcriptional regulators, DNA or RNA binding proteins and translation elongation factors.

Using a normalized library from whole fly bodies and 3' end Sanger sequencing of clones, we generated a functionally diverse collection of 6,607 EST contigs, the majority of which encoded peptides in addition to 3' UTRs.