Sentence examples for adding aprepitant for from inspiring English sources
The effectiveness of adding aprepitant for CINV treatment in moderate emetogenic chemotherapy is also unknown.
Incremental cost-effectiveness ratios compared with standard therapy alone were $US172 789 for aprepitant plus a corticosteroid, and $US160 236 for adding aprepitant after CINV.
A cost-consequence study that included costs for aprepitant plus standard antiemetics for a hypothetical group of 1000 patients receiving a single cycle of highly emetogenic chemotherapy concluded that savings in overall direct medical costs would offset 58.7% (range 20 80%) of the incremental cost of adding aprepitant (Bell et al. 2004).
One provides evidence that the benefits of adding aprepitant are maintained through multiple cycles of chemotherapy (de Wit et al. 2004), with complete response in the sixth cycle in 59% of the aprepitant group, compared with 40% for standard therapy (Table 4).
A further analysis investigated the efficacy of adding aprepitant in patients receiving moderately emetogenic chemotherapy with cyclophosphamide and/or doxorubicin as well as cisplatin (Gralla et al. 2005).
In patients receiving moderately and highly emetogenic chemotherapy, adding aprepitant to standard antiemetic therapy with dexamethasone and a serotonin antagonist significantly improved control of CINV.
Merck has been working on aprepitant for more than a decade and stuck with the program even after early tests in humans showed that it worked no better than placebos.
We had thus overestimated the benefit of aprepitant for the prevention of non-AC MEC.
Although current guidelines recommend 3-day dosing with aprepitant for the prevention of CINV, previous studies indicated that single-dose aprepitant conferred antiemetic effects for acute and delayed CINV [ 6, 7].
Single-dose fosaprepitant could be used as an alternative to 3-day aprepitant for the prevention of CINV.
However, the effectiveness of aprepitant for postoperative pain control in relation to substance P warrants further investigation.
