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Apart from the group variable indicating the use of a PCT algorithm, we included important prognostic factors such as patient age and ARI diagnosis as additional fixed effects; to account for within-and between-trial variability, we added trial to the model as a random effect.
In the CHARM Added trial, hyperkalaemia was almost five times more common and increased creatinine levels twice as common with dual therapy than with monotherapy.
With the exception of the CHARM Added trial, 18 most if not all data making dual therapy attractive are based on evidence from surrogate endpoints.
In the CHARM Added trial, 18 in a cohort of 2548 patients with heart failure, dual blockade of the renin-angiotensin system (candesartan and ACE inhibitor) significantly reduced the primary outcome of cardiovascular death or admission to hospital for worsening of heart failure.
Similar(56)
In Experiment 2, to rule out the possibility that the observed correlations were due to reward expectancy, we repeated the same procedure but added trials in which sucrose delivery was replaced by an aversive air puff stimulus.
The top (a) panel depicts a No-change trial, the middle (b) panel a Remove trial, and the bottom (c) panel an Add trial.
But now, he adds, trial lawyers are making burdensome electronic discovery requests as a ploy to gain settlement leverage and if the data can't be retrieved to make it look like there's a cover-up.
These guidelines address acceptable reliability and the gains achieved by adding trials or increasing trial length.
We continue to add trials to this list on a regular basis.
A way to eliminate the influence of evoked responses completely is to add trials in which a target is expected but not actually presented (as suggested in Van Diepen et al.7).7
For Add trials, four sounds were presented in scene A and the fifth sound was introduced in scene X.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com