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Such type of event could add to mutation pressure away from preferred codons at unconstrained sites (Akashi 1994).
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While possibly involved in the repair of AID-induced DNA damage, RR is also likely to add to the mutation signature of AID by introducing deletions and inversions of repetitive sequences.
Starting from low mutation rates, each time a sequence is mutated, a small positive random number is added to its mutation rate (if the distribution is unbiased and negative numbers can be drawn, mutation rate decreases).
Also, the diploid nature of these strains possibly allows for a greater accumulation of mutants than a haploid strain would [ 42, 44] because undesired mutations would not be selected against and could thus be inherited and add to the accumulation of mutations as long as one functional wild type allele remains in the genome.
The colors of the peaks indicate the nature of the specific dideoxynucleotide that was added to the mutation detection probe.
New instances were added to the Mutation and Motif classes to capture information on kinase structural motifs and subdomains.
We mentioned in the text that clonal selection for more aggressive growth of cancer cells could add to changing proportion of different mutations.
These findings add to the evidence that TMC mutations may influence the risk of species 2 betaHPV infections.
According to all models cited above, deleterious mutations should add to the fitness variance in the population and, hence, increase the amount of interference selection.
Smith MJ, Isidor B, Beetz C, et al. Mutations in LZTR1 add to the complex heterogeneity of schwannomatosis.
It also adds that somatic de novo mutations are highly variable, may depend on tissue and age of the individual, and could add to predisposition for disease.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com