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Upcoming clinical trials will most likely assess add-on effects of vitamin D3 on current immune modulating drugs.
Small but statistically significant add-on effects of psychotherapy on the quality of life of chronically depressed patients were demonstrated.
Studies focusing on the add-on effects of angiotensin II type 1 receptor blockers (ARBs) other than their antihypertensive effect are receiving attention.
This study evaluated the add-on effects of these factors and designed a simple prognostic risk score to assess the prognosis of these patients.
Therefore, we investigated why chitosan-loaded chewing gum showed add-on effects to sevelamer hydrochloride based on quantitative analysis of Savica et al.'s report [ 15].
The aims of our study were to identify the predictors of mortality in patients treated with CRT and to design a risk score for mortality, considering the add-on effects of the predictors.
In the present study, the respective add-on effects of benidipine and amlodipine on albuminuria reduction were demonstrated in 100 CKD patients on top of the ARBs telmisartan and olmesartan.
However, the add-on effects of aripiprazole in reversing antipsychotic-induced HPRL depend on the pharmacological properties of the pre-existing antipsychotic; adjunctive aripiprazole treatment reverses effectively HPRL induced by risperidone and olanzapine, but seems to be less effective for that induced by benzamide antipsychotics (amisulpride and sulpiride) [ 226, 233].
In this context, gene therapy does not have to be used as a monotherapy but rather should be combined with other conventional modalities to seek for the so-called add-on effects since gene medicine itself is demonstrated as safe in many clinical trials.
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