"The logical conclusion is that we're going to need add-on agents in order to lower event rates (heart attacks).
For patients where TB remains persistent despite prolonged therapy with second-line TB drugs, the add-on agents including bedaquiline and delamanid are recommended for salvage therapy (Günther, 2014; WHO, 2014; Shim and Jo, 2013).
15 Nevertheless, remarkably little is known about metabolic advantages of these two add-on agents, and most studies were small.
The company says that they've got more agents in the works, potentially offering add-on agent "suites" tailored to certain use cases — one set that'd be good for school, one set that'd be good for work, etc.
In addition, saxagliptin is approved for use as an add-on agent or for first-line therapy.
23 Dapagliflozin was demonstrated to be noninferior to glipizide, as an add-on agent to metformin; both groups' HbA1c declined by −0.52% at 52 weeks.
Leung and colleagues [ 93] tested the hypothesis that using gabapentin as an add-on agent for treating postoperative pain reduces the occurrence of postoperative delirium.
In a pilot randomized clinical trial, use of gabapentin as an add-on agent of postoperative analgesia reduced the occurrence of postoperative delirium, possibly due to its opioid-sparing effect [ 26].
Based on the well-known observation of the aldosterone-escape phenomenon under single RAS blockade with either an ACE inhibitor or an ARB (36), Schjoedt et al. (37) examined the effect of spironolactone as an add-on agent to other RAS blockers on nephritic-range albuminuria in patients with diabetic nephropathy.
"We don't add on more than one new agent a year because if we did, everyone would trip over everyone else," said Carol Brown, one of the firm's three owners.
Then it went to the full Senate, where the sponsors agreed to add on another 20,000 border agents and expand the wall-like border fence to 700 miles.
