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We believe that the 50 million compound pairs from the 10-K set are also enough for the multiple-conformer approach such that adding more compound pairs in the distributions in Figure 4 is not likely to change much.
Let that dry, and continue sanding and adding more compound until the surface is even and smooth.
After initial fixes that allowed the core metabolites to be produced, we incrementally added more compounds to the biomass.
The second publication, expanded on the Webster analysis by adding more compounds (n = 53) and adding subcategories: antiarrhythmic drugs, drugs withdrawn for TdP/QTc prolongation, those probably associated with TdP, those possibly associated with TdP, and those not associated with TdP.
Remove the piece from the bag each morning and examine it thoroughly, then add more aging compound if necessary and repeat the process if you want to get more color on the piece.
And clever ideas for financial engineering, like financing infrastructure projects by selling new city bonds to the pension funds of municipal unions, will just add more debt, compounding the problem of how to pay all the interest and principal.
The trend in reactivity in these compounds is that as we add more double bonds we increase the reactivity of the compound.
This "platform overhead" only compounds as you add more features, leading to a fragmented and potentially frustrating customer experience.
This does not imply that Thal, Bort, and Len have no effect on OS, but instead suggests that these compounds do not add more explanatory power on median OS other than their effect through median TDE.
You can always sand away excess compound — you can't add more once you begin painting.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com