Sentence examples for adaptive two-stage design from inspiring English sources

It is well known that flexibility is one of the major advantages of an adaptive two-stage design, and the intended adaptation should be as preplanned as possible to maintain the integrity of the clinical trial.

Following an adaptive two-stage design of O'Brien and Fleming (1979) type, a real data example is worked out in detail.

Banerjee and Tsiatis (2006) proposed an adaptive two-stage design which allows the sample size at the second stage to depend on the results at the first stage.

Based on the FDA FDAA 2013) and Health Canada Health Canadaa 2012) recommendations, an adaptive two-stage design was used because within-participant CV estimates for diazoxide were not available.

However, the adaptive two-stage design implemented in this trial allows a data-driven modification of the sample size of the second stage based on the results of the interim analysis or on external information while the specified significance level is controlled when the decision rules defined above are adhered to [ 35].

A two-stage design was employed.

Simon's two-stage design will be used to assess the feasibility of POC RBC washing.

This study employed an optimal but flexible two-stage design with an early stopping rule.

Simon R. Optimal two-stage designs for phase II clinical trials.

We use stepped wedge and learn as you go research designs, two-stage designs and quasi-experimental designs that utilize and integrate existing stores of previously untapped data.

For this reason, an adaptive version of Simon's optimal two-stage design is used for this Phase II study part [ 23, 24].