Along with presenting a proof-of-principle study, we discuss a mechanism for the apparently counter-adaptive persistence of immunopathology in natural populations.
Taken together, the population-level endemism, specificity and stability exhibited by Symbiodinium raises concerns about the long-term adaptive capacity and persistence of these symbioses in an uncertain future of climate change.
The observed reassembly of one of the enzymes in the WTA machinery may allow for adaptive colonization and persistence in a particular human host.
Conceivably, this family of evolutionary conserved proteins provides a generalized mechanism by which parasites interfere with the adaptive response to maintain persistence in the mammalian host and completion of their life cycles.
By contrast, in IIM, muscle fibers are direct targets of adaptive response, and the persistence and clonal expansion of autoreactive T cells prevent muscle healing.
In the following, we focus on the consequences of genetic drift, inbreeding, and inbreeding depression for adaptive responses and the persistence of biodiversity under stressful conditions.
The adaptive advantage for allowing persistence of pathogens within the CNS is argued to be an adaptive balance between limiting disruption of CNS function by the pathogen compared with by the pro-inflammatory responses of immune cells.
The Hawaiian honeycreepers (Drepanidinae) are one of the best-known examples of an adaptive radiation, but their persistence today is threatened by the introduction of exotic pathogens and their vector, the mosquito Culex quinquefasciatus.
Pandemic H1N1 patients with severe respiratory disease and poor outcomes are characterized by an impaired activation of those genes participating in the development of the antiviral adaptive response and by persistence of the virus in the respiratory tract.
