Sentence examples for adaptive perk from inspiring English sources

The adaptive PERK pathway functions to restore ER proteostasis by reducing overall protein synthesis via phosphorylation of eIF2α and increasing the expression of UPR responsive genes via the production of the transcription factor ATF4. PERK activation increases BACE levels and thus Aβ formation.

Taken together, our current observations suggest a working model where TMEM33 may function as a critical determinant of the balance between PERK and IRE1α-mediated apoptotic, adaptive and neoplastic transformation events in cancer cells (Fig.  8).

ER sensor proteins such as IRE1 and PERK are involved in both the adaptive and the proapoptotic UPR pathways.

For example, one ER stressor (ATF6) has a cardioprotective role [ 147, 148] while two others (IRE1 α and PERK) are involved in both the adaptive and proapoptotic UPR pathways.

Sequestering of chaperones by misfolded proteins in the ER is rapidly sensed by three sensor proteins: IRE1, PERK, and ATF6, and launches the three-armed adaptive stress response of the ER.

Many downstream target genes of the UPR are co-regulated by IRE1α, PERK, and ATF6α, ensuring the redundancy and robustness of this adaptive response.

Following the rapid activation, we observe a slow but steady decrease in the activated IRE1 α and PERK, which is associated with the gradual accumulation of BiP as a result of the initiation of the adaptive response.

Be adaptive.

The Perk!

What is adaptive learning?

Perhaps this is adaptive.