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The whole field of adaptive experiments and intelligent scheduling is a significant area of study in itself, with considerations potentially extending beyond pure science into issues such as logistics and economics.
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"From a management and science perspective, this is a very large adaptive experiment [with] a lot of unknowns," he said in a phone interview with ScienceInsider.
This hypothesis should be tested and refined via adaptive management experiments.
The adaptive evolution experiments were performed with 40 passages in YNB medium and isolated clones were screened.
The numerical values of the parameters in the model are identified in towing tests and adaptive maneuvering experiments for a scaled model ship in a marine control laboratory.
The adaptive evolution experiments were performed in 500 mL flasks at 28°C/160 rpm filled with 100 mL of YNB (0.7% yeast nitrogen base without amino acids; 0.01% histidine; 0.01% leucine; 0.01% metionine) containing 2% xylose.
It is interesting to note that in adaptive evolution experiments using a chemostat to continuously alter grow conditions often results in changes in Hfq (Bernard Palsson, UCSD, personal communication).
To study the role of FcγRIIa in different populations of cells, adaptive transfer experiments could be performed.
In our adaptive evolution experiments, we kept the 0 hour seed and first generation cultures as positive controls.
Adaptive evolution experiments performed on the engineered strains actually showed that lactic acid production was coupled to growth and achieved increased secretion rates of the product.
Furthermore, many laboratory strains are not necessarily evolved for maximization of growth and thus do not meet the FBA predicted growth rate prior to adaptive evolution experiments [ 44].
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