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The adaptive design strategy is a feasible approach for optimal designs in dose-finding studies, where the information matrices usually depend on the unknown parameters.
In this phase II trial, patients are randomized to receive letrozole in combination with everolimus or placebo, an adaptive design strategy, so that identification of biomarkers can be used to optimize patient selection for a future phase III trial of first-line combination therapy in patients with advanced breast cancer.
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For example, some adaptive design strategies increase the probability of receiving the more effective treatment while maintaining the scientific rigor of the trial [ 10, 15].
The research findings postulated two paradigms in climate-adaptive design strategy: 1) the precise composition of urban canopy directly impacts the thermal comfort of urban open space; and 2) the comprehensive site configuration significantly influences the personal evaluation of health perception.
Therefore, there exists, at least, one adaptive control design strategy with limited plant model information that can achieve a competitive ratio equal to one.
Based on the above findings, a framework is conceptualized as an attempt to strengthen the climate-adaptive open space design strategy.
First, an effective distributed adaptive gain-design strategy is proposed based only on local information of the network structure.
How to deploy passive building design strategy adaptive to climate change scenarios at urban neighbourhood level is currently not well understood.
This paper presents an adaptive nonlinear predictive control design strategy for a kind of nonlinear systems with output feedback coupling and results in the improvement of regulatory capacity for reference tracking, robustness and disturbance rejection.
In this work, a design strategy for adaptive observers is presented for a type of T-S systems with unknown parameters.
The control performance of the feedback error learning method as a design strategy of adaptive control has been demonstrated by simulation results.
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