We implanted chronic intrathecal catheters, which permitted delivery of multiple doses of miRNA inhibitors or mimics, adapting regimens previously described for delivering small interfering RNAs to DRGs in rats in vivo (Whitehead et al, 2009; Wu et al, 2010).
Population pharmacokinetic modelling and developmental approach enabled to perform simulations, which showed that continuous infusion was the most adapted dosing regimen, for children over 1 month of age.
Altogether, these advances in the fundamental and experimental knowledge on OA may allow for the generation of improved, adapted therapeutic regimens to treat human OA.
Carefully adapting her regimen to Donna's daily progress, Liz helped her improve her balance and flexibility and strengthen the muscles supporting her knee, and also gave feedback on how to avoid favoring one side so Donna wouldn't develop problematic long-term habits.
In any case, although BVD had acceptable tolerability in the whole study population of median age 68 years, caution is warranted when considering this triple regimen for patients older than 70 years, in which an adapted dose BVD regimen should be considered.
The drug was not approved for the treatment of AML in the US although further studies of decitabine in the US resulted in the creation of a prolonged 10-day dosing regimen, which may prove more effective than the original 5-day regimen adapted from myelodysplastic syndrome (MDS).
Nevertheless, despite a regimen adapted to renal function, patients treated with piperacillin-tazobactam had a higher percentage of adequate concentrations when CrCl was below 50 mL/min.
The purpose of this study was to investigate the efficacy and safety of a body-weight adapted oral dosing regimen of cholecalciferol in dialysis patients.
After almost three years of treatment sputum conversion was achieved with a treatment regimen adapted to the last DST including INH, EMB, Am, Mxf, p-aminosalicylic acid, terizidone.
The aim of our present work was to predict in burn patients the best adapted ceftazidime dosage regimen to obtain a serum target of 40 to 100 mg/l taking into account the influence of patients' characteristics on ceftazidime pharmacokinetics (PK).
