For LMWH, doses must be adapted in case of extreme body weight (body mass index above 30 kg/m²) and poor renal function.
By the time of the second visit, all microbiological laboratory results will be available and the treatment may be adapted in case of a specific detected pathogen or an unsatisfactory clinical evolution.
Duration of treatment in non-neutropenic patients is recommended for at least 14 days after the first negative blood culture and resolution of signs and symptoms of candidemia (BIII) [ 127, 153, 178], but should be adapted in case of organ manifestations.
Finally we discussed how habitat reduction could compromise long-term survival of the species by reducing genetic diversity and thus their ability to adapt in case of environmental changes.
A robustness test was done for all the scenarios used, to ensure that the proposed algorithms are able to adapt in case of a sudden change in the tap weights of the filter, either in the transient or steady state stage.
Furthermore, methods to enable a systematic identification of areas limiting generalizability and transferability need to be adapted in case a HTA is adapted for a different country.
Considering the observed toxicity and the frequent dose reduction, we recommend a lower starting dose of 1000 mg m−2 orally twice daily and to adapt dosages in cases of decreased creatinine clearance.
A similar recommendation can be adapted in the case of Masindi district.
This method is particularly adapted in the case of high-dimensional data to avoid multi-colinearity problems.
For the second stage we use the equilibrium concentrations obtained in the first stage as initial conditions, the parameters are adapted and in case of the laser ablation scenario the tissue topology is adapted.
