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We then simulated a 60-year life cycle for annual estimates of DBH using our adapted growth functions.
In some experiments, cultures exhibiting this adapted growth phenotype were perfused with 64 μg/ml nikkomycin Z in combination with caspofungin, but this did not inhibit growth (Fig. 3d).
Thus our findings may explain the often-encountered clinical scenario, wherein tumors shrink or even transitorily disappear with chemotherapy followed by subsequent local recurrence or adapted growth at distal locations, which is hypothesized to be tightly linked with the biology of CICs.
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Inhibition of ethylene perception in horizontally stimulated maize roots growing on surfaces eliminated the capacity of the roots to adapt growth to the surface and a vertical orientation of the root tip.
Due to the sessile nature of plants, it is essential for them to sense their environmental and internal nutrient levels, in order to allow proper responses to temporal and permanent limitations, and to adapt growth to the resources available.
To adapt growth to the resource status, plants rely on specific long-distance growth signals that mediate the communication between the root and the shoot.
Previous reports show that isolated grayling populations derived from a single ancestral population rapidly adapt growth rates to local environmental conditions, even under strong influence of genetic drift [ 14, 47, 48].
The objective of this study was to exploit natural variation within the gene pool of Arabidopsis thaliana to identify additional components of the complex signaling network that plants use to adapt growth to changes in ambient temperature.
Identification of the genetic elements associated with these traits will provide targets for the future development of crops adapted to growth in low Pi soils.
The low- B/A ecotype strains instead are adapted to growth at high light intensities, where the growth of high B/A ecotype strains is inhibited.
Remarkably, none of the variants we observed correspond to the variants described in an earlier study, in which a PR8 strain (originally adapted for growth on embryonated chicken eggs) was adapted for growth on MDCK cells [ 78].
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