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The adaptation of these methods for Pakistan and validation of the diagnostic questionnaire are described here.

This subtle balancing of stochastic error with spatio-temporal error, together with a novel MLMC estimator for the statistical moments are the key ingredients in the successful adaptation of these methods to different UQ contexts.

Many other TNF superfamily molecules have been found to have antitumor potential [90] and these could also be tested against B16F10 tumors using an adaptation of these methods (as an example, note the antitumor effects shown for pSP-D-GITRL in Fig. 1).

The approach described here builds on methods developed for studying epidemics in the community (21– 23) and a recent adaptation of these methods to hospital populations (24).

The adaptation of these methods to merge with current developments in quantitative IHC (for example, AQUA) and image analysis could further standardize delivery of multiplex panels that are far more cost-effective than complex molecular profiling.

Such approaches do not exclude the use of a wide range of methods (including western), but instead demand the interrogation and/or adaptation of these methods with respect to: cultural sensitivity; cross-cultural reliability; outcome utility; and other such measures, to meet the needs of the indigenous participants and community [ 22, 26].

We have been unable to identify any major published studies which perform ITSA on unplanned events with poorly identified time points, but the unique nature and large scale of unplanned events such as the Australian Heroin Shortage demand an adaptation of these methods in order to better understand the effects of such events on various indicators of drug use and drug-related harm.

Lead levels were measured in red blood cells using adaptations of the methods described by Miller et al. [ 16] and Parsons and Slavin [ 17].

Two previously reported methods and adaptations of these previously reported methods were performed and compared for optimized reproducibility, metabolite detection, and signal intensity.

For DHB, two previously reported methods and two adaptations of these previously reported methods were performed and compared for optimized reproducibility, metabolite detection, and signal intensity.

We here describe adaptations of the method that yields converged solutions.

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