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The surplus of 9 ms within the 105 ms window (ten samples) compared to the non-adaptive filter only occurs during the first adaptation sample which takes 1.7 ms+9 ms=10.7 ms in total.
In the cultural adaptation sample, the test-retest correlation between GAD-2 scores (extracted from the GAD-7) was 0.744.
Cluster 1 and Cluster 2 contain genes that are respectively induced or repressed during stress adaptation (Sample B).
However, Cluster 3 contains genes that are induced both by stress adaptation (Sample B) and recovery from stress (Sample D).
The GAD-2 vs GAD-7 concordance sample was recruited following the same inclusion/exclusion criteria used in the cultural adaptation sample.
In the version concordance sample, Cronbach's alpha for the GAD-2 was 0.927, which is close to the value of 0.936 obtained in the cultural adaptation sample.
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All previous work on trial adaptation by sample size adjustment addresses the question of whether the sample size can be reduced while maintaining a certain level of statistical significance of the trial's outcome.
Most existing work on trial adaptation by sample size adjustment adopts the frequentist paradigm.
A planned adaptation to sample size in an ongoing trial aims at providing an opportunity to modify design assumptions made at the trial planning stage.
Previous research on clinical trial adaptation by sample size reduction has universally focused on the question of when such reduction should be performed.
Unlike most of the previously published work, our approach focuses on trial adaptation by sample size adjustment, i.e. by reducing the number of trial participants in a statistically informed manner.
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