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This complex microvascular network is responsible for regulation of vascular tone, adaptation of tissue oxygenation to local metabolic demand, exchange of nutrients and waste products between blood and cells, and regulation of immune response [59].
In other environmental applications, this model can be used to screen and design plants targeted for phytoremediation of aromatic pollutants and adaptation of plants in various stressed environments, including outdoor adaptation of tissue culture and transplanted seedlings for better food production.
We present a cell migration assay in a 384 well plate format through the adaptation of tissue culture cell wound healing.
Several studies have suggested that cell lines exhibit a narrow range of genetic profiles, harbor genetic alterations due to adaptation of tissue culture environment, and are poor predictors of in vivo sensitivity to drug efficacy [ 1- 3].
This complex microvascular network is responsible for regulation of vascular tone, adaptation of tissue oxygenation to local metabolic demand, exchange of nutrients and waste products between blood and cells, and regulation of immune response [ 59].
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It is also important to note that from birth toward adulthood and aging or during induction of diseases, the multi-cellular organ systems of the human body is subject to continuous energy-demanding wear and tear processes in order to accommodate the Yin and Yang events and the repairing, remodeling and adaptation of tissues.
However, in our rat model the serum inflammatory cytokine response can resolve to baseline levels in HRLF and LRHF rats, despite continued task performance for as long as 24 weeks, presumably due to down regulation by anti-inflammatory cytokines or adaptation of tissues to task demands [ 55, 59, 67].
Finally, this modelling approach demonstrates that both absence of desmin and adaptation of connective tissue are required to explain the increase in passive stiffness in desmin knockout muscles.
Research suggests that control of epigenetic adaptation of connective tissue ECMs is largely provided by resident fibroblasts which transduce mechanical loads to effect an optimized remodelling response [2] [9].
We hypothesize that this response corresponds to an adaptation of the tissue to this stress.
Changes in the expression of genes have to be considered a medium-to-long term adaptation of the tissue to a new physiological state.
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