In this way, the controller can account for the therapeutic regime-dependent influence of medications and inter-medication synergy on clinical responses, while making use of dose-response measurements for online adaptation of dose-response models.
During maintenance therapy, SOP conformity required adaptation of dosing regimen according to therapeutic drug monitoring.
However, perhaps of more interest is adaptation of dosing based on T-cell count, which has been explored in kidney and heart transplantation (Table 1).
An interesting point is that piperacillin concentration in the dialysate effluent is equal to the free plasma concentration and can therefore be used for the individual adaptation of the dose via therapeutic drug monitoring (TDM) [43].
Angular tube current modulation further equalizes in real time the photon flux to the detector as the X-ray tube rotates about the patient among the anteroposterior and lateral position according to the measured attenuation from the previous projection, allowing further adaptation of the dose for the anatomy of the patient [14, 15].
The reason for the discrepancy was that G-BA accepted evidence versus the comparator used in the phase III trials while IQWiG disagreed with the ACT due to lack of adaptation of steroid dose within those trials.
Application of this modality to anal cancer may allow adaptation of radiotherapy dosing, both intensification and de-escalation, to compensate for observed tumour biology.
Twelve patients require more than one adaptation of DA doses during the study: these patients are the one who suffered of the most events.
Cranial radiation was the main risk factor for development of late effects; however, adaptation of high-dose methotrexate and intrathecal chemotherapy as CNS-directed therapy has led to a substantial improvement in neurodevelopmental outcome.
Irrespective of their origin, the documented seasonal variations of HbA1c levels should be considered in disease management schedules: adaptation of insulin doses, meal plans, advising and organising physical activity, prevention of physical activity-related fear of hypoglycaemia in young patients with type 1 diabetes and the use of HbA1c as a tool for diabetes diagnosis.
