The phrase "adaptation mutation" is not standard in written English and may cause confusion.
It could be used in a scientific context when discussing genetic changes that occur as a result of adaptation, but it is not a commonly recognized term.
Example: "The study focused on the role of adaptation mutation in the evolution of species in response to environmental changes."
Alternatives: "adaptive mutation" or "mutation for adaptation".
The E627K substitution is the best characterized mammalian adaptation mutation.
The affinity for human receptors is associated with the mammalian adaptation mutation Q226L.
This allowed for a test of efficiency of the new sigmoidally-determined adaptation mutation rate GA against the 20% fixed mutation rate GA and a test of accuracy for the sigmoidally-determined adaptation mutation rate GA against the 0% fixed mutation rate (no mutation) GA.
The optimization procedure is based on evolutionary strategies which are implemented with JavaEva (WSI Computer Science Department, Center for Bioinformatics, University of Tübingen, Germany) and a MVA (main vector adaptation) mutation operator [ 73].
In contrast with all avian viruses within this clade, the current human isolate contains the mammalian adaptation mutation PB2-E627K, A/Sichuan/26221/20142014 has acquired PB2-D701N, suggesting a rapid acquisition of mammalian adaptation changes that likely arose after human infection.
The importance of these Vero cell adaptation mutations in flavivirus vaccine design and development is discussed.
Recombinant viruses encoding various combinations of these Vero cell adaptation mutations did not demonstrate enhanced replication in Vero cells over that exhibited by the single mutations.
DEN4 viruses bearing these Vero cell adaptation mutations were also evaluated for the level of replication in the brains of mice.
Finally, addition of a subset of the above non-attenuating, adaptation mutations to a DEN2/4 chimeric vaccine candidate was found to increase the virus yield in Vero cells by up to 500-fold.
The WS genotype is not static either, as WS genotypes are known to accumulate measurable metabolic defects and reduced fitness within 100 generations, whilst compensatory adaptation (mutations which lead to an increase in fitness) in WS lineages has been seen within a similar interval in liquid microcosms [25].
Mammalian adaptation mutations are also observed in the polymerase basic 2 (PB2) gene of the virus [ 2, 9].
