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The general process of model-based trial design and analysis is described and several examples demonstrate the value in historical data, simulation-guided design, model-based analysis and trial adaptation informed by interim analysis.
The conclusion section identifies the implications of these findings in the light of emerging best practice in adaptation informed by a 'social determinants of health' definition of climate vulnerability.
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Although a typology cannot be comprehensive [ 16], it may benefit from adaptations informed by research.
However, if our adaptation is informed by science cherry-picked to support a particular standpoint on "dangerous climate change" then this risks leading to wrong decisions on adaptation.
The selection of the intervention for adaptation was informed by the method of its delivery and the quality of prior evidence.
Figure 2 summarises this literature, providing the available elements of a best practice approach for developing national adaptation policy informed by a focus on vulnerable groups in ways that are consistent with the definition of climate vulnerability and the prescriptions of global policy frameworks discussed in the background section of this paper.
Public health professionals will be critical to adaptation strategies, hopefully informed by an evolutionary perspective about the interrelations between living things and their environments.
The adaptation process was informed by detailed qualitative research within the target population.
With societies worldwide already beginning to face the impacts of climate change, there is an increased urgency to design and implement adaptation measures that are informed by robust climate science.
This process should follow a framework that addresses a key set of shared national adaptation functions, and would be informed by lessons learned from the existing National Adaptation Programs of Action (NAPAs).
With a case study of Wu Hsing-kuo's solo adaptation of King Lear, Lear Is Here,[i] one of many recent Asian adaptations of Shakespeare that are informed by performative auto/biographies, this paper addresses these questions by rethinking the problematic status of "foreignness" and locality in the age of globalization.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com