Joints are physiologically exposed to mechanical stress, which triggers gene expression and metabolic activity of chondrocytes in order to turn over the extra cellular matrix and eventually adapt the tissue to loading.
Skeletal muscle displays a striking plasticity, mature muscle cells undergoing drastic changes in their size and specific protein content to adapt the tissue to different levels of mechanical stimulation or nutrient income, or to hypercatabolic pathological situations [ 39]. mTOR signaling is known to play a central role in the mechanisms that control muscle plasticity [ 15].
In the early pregnant porcine myometrium, these proteins regulate tissue rebuilding, thereby adapting the tissue to the developing pregnancy (Thilander and Rodriguez-Martinez 1989).
Immature articular cartilage is the template upon which biomechanical and biochemical cues act in adapting the tissue to joint-specific function through induction of morphological, structural and biomolecular heterogeneity [26].
In view of the progress that has been made in the demonstration of the neurofibrillary changes of the Alzheimer type, it seemed expedient to revise the 1991 staging procedure by introducing immunoreactions for visualization of hyperphosphorylated tau and by adapting the tissue selection and processing to the demands of the routine diagnostic laboratory.
We adapted the tissue specificity index, τ. to investigate how narrow Nups network genes expression is across development: where N is the number of stages being compared, E i is the expression in stage i, and Emax is the maximum expression reached by the gene across stages (Yanai et al. 2005).
Macrophages show a high degree of plasticity and they adapt to the tissue environment [51], often developing properties that do not precisely fit into the in vitro generated M1 or M2 profiles, e.g. macrophages in lung tissue [52] or in tumors (reviewed in [53]).
Additionally, we hypothesize that metastases from gastrointestinal origin either remember their tissue of origin or adapt to the tissue of destination.
These cells, and presumably the tissues they originated from, have the ability to survive hypoxic growth conditions and must be able to adapt to the tissue environment.
To adapt the protocol for fly tissue, we made two changes to this previously described protocol: First, we changed the lectin used from wheat germ agglutinin (WGA) to Concanavalin A (ConA).
In the new study, the researchers set out to adapt the expansion process for biopsy tissue samples, which are usually embedded in paraffin wax, flash frozen, or stained with a chemical that makes cellular structures more visible.
