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(DOCX 13 kb) Additional file 2: R code to reproduce or adapt study methods.
In light of this, it is important to adapt study methods to context-specific barriers and overcome inherent application problems, which would otherwise hinder such economic evaluations.
There were fewer participants in this study than ADAPT, because only Cambridgeshire participants were recruited, and recruitment started later than the wider ADAPT study.
A further analysis using ADAPT study patients, TIMI 0 and a high-sensitivity troponin assay (Abbott Architect high-sensitivity TnI) reported a NPV of 100%95%5% CI 98.8% to 100%) [12].
A subsequent analysis of an Australasian cohort largely but not completely overlapping with the ASPECT cohort explored TIMI score 0, normal ECG and normal troponin I using Beckmann Coulter AccuTnI in Australian patients and Abbott Architect cTnI in New Zealand patients (the ADAPT study) [9].
The National Institute on Aging (NIA) funded the "ADAPT" study, involving 2,400 volunteer participants given naproxen, ibuprofen or a placebo.
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Finally, we emphasize the importance of adapting study design to the question addressed.
Pilot-testing of the adapted Study on Lifestyle intervention and Impaired glucose tolerance Maastricht (SLIM) and to determine its feasibility and likelihood of achieving desired impact.
Adapted study designs will be needed and may include observational, experimental and pragmatic trials using registries.
WCM, principal investigator, adapted study concept to Veterans Administration guidelines, oversaw scientific integrity and interpretation of data, and provided critical review of the manuscript.
It is obvious that new product assessments should be based on adapted studies using state-of-the-art experiments.
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