Biological materials solve this challenge by adapting a structure that is intrinsically capable of mitigating structural irregularities or flaws while maintaining high performance, representing a built-in capability to tolerate defects.
This process of adapting a structure to a new function was given the name "exaptation" by Gould.
At any pH condition, due to the presence of both types of charges on the protein molecule, the charge on the substrate will eventually find a balancing charge on the protein molecule provided that the protein molecule is flexible enough to adapt a required structure for adsorption [ 49].
Therefore, despite the sequence differences, it is possible that the 6 repeatspeats found in some AtFYVE adapt a β-propeller structure similar to β-propeller structures found in proteins from other organisms.
We adapt a collection of neighborhood structures, k-opt, double-bridge and insertion operators mainly used for solving the classical travelling salesman problem.
Note that while β1−β2 and β3−β4 adapt an 'open' conformation in the structure shown in green (average separation of over 18 Å), the red structure shows the binding regions 'close' to each other (average separation of 13.5 Å).
The G-DRG system was designed for reimbursement calculation, but developed to a standard with strategic management implications, generalized by the idea of adapting a hospital's cost structures to DRG revenues.
Hence, in theory model trees can better adapt their structure to a diverse set of compounds, such as the Vss-target dataset used in this work.
Upon activation of PERK, its cytosolic kinase domain adapts a back-to-back dimer structure, and its dimerization is driven by PERK ER lumen domain dimerization.
Part of the explanation for the brain's apparent resilience is its 'plasticity' – an ability to adapt its structure based on experience.
