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The phrase "acutely uneasy" is correct and usable in written English.
It can be used to describe a strong feeling of discomfort or anxiety about a situation.
Example: "As the meeting approached, she felt acutely uneasy about presenting her ideas to the board."
Alternatives: "deeply unsettled" or "intensely anxious".
Exact(3)
And the Fed, acutely uneasy with this new role in the American economy, may now find itself unable to avoid doubling down.
It makes Germans acutely uneasy that their country is too strong while Europe is too weak, but Merkel never discusses the problem.
Having patented these influential ideas, Kristeva is now acutely uneasy at being chained to her own thought, or confined within her own thinking.
Similar(57)
He was acutely aware that he was different from other children, and that some people were uneasy around him.
Acutely problematic.
Why uneasy?
Patient is acutely ill.
Uneasy relationships.
"Uneasy wedlock".
Wilson felt the loss acutely.
But John is uneasy.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com