Acute toxicity is initiated by depletion of acutely responding epithelial tissues and damage to microvessels [ 10].
For example, unlike lung adenocarcinomas with sequence-altering mutations of EGFR, tumors with amplifications of EGFR do not acutely respond to EGFR tyrosine kinase inhibitors.
Moreover, pretreatment of aerobic cells with antimycin A abrogates the transient response of a large number of networks that acutely respond to anoxia yet has not affect heme-regulated ones (e.g., Hap1, Rox1 and Upc2) that more chronically respond.
The relationships between total dose and dose per fraction for acutely responding tissues (i.e., high-turnover tissues), late responding tissues (low or no turnover), and tumours provided the basic information required to optimize radiotherapy according to the dose per fraction and number of fractions.
The CB contains neuron-like, O2-sensitive, glomus (type I) cells that acutely respond to hypoxia by the release of neurotransmitters that stimulate afferent nerve fibers, which activate the brain stem respiratory center and increase sympathetic tone (Lopez-Barneo et al, 2001).
Using c-Fos immunoreactivity as a marker for neuronal activation, it has been found that vM1 volume acutely responding to facial nerve axotomy in sighted rats is twofold smaller than in blind animals and that the degree of acute cortical activation is directly related to the degree of late motor recovery [ 14].
The expression of several clock genes acutely responds to light in zebrafish cells, e.g. per1, per2 and cry1a [22], [23], [24], [24].
He noted that delirium and mania presented acutely and responded to the traditional treatment for bipolar mania.
I felt inclined to neither but responded, acutely, to the legitimate horror depicted.
Mr. Slatkin, who orchestrated one of the "Promenade" sections and changed some dynamic marking to reflect the composer's intentions better, seemed to enjoy conducting the work, and the orchestra responded acutely, ending the evening as evocatively as it had begun.
