Therefore, DAGs acutely and directly stimulate some of the TRPCs, but they also activate or inhibit TRPCs by triggering protein kinase C-dependent phosphorylation.
While rapamycin acutely and directly inhibits mTORC1, only chronic administration of rapamycin can inhibit mTORC2 in some, but not all, cell lines or tissues.
While rapamycin acutely and directly inhibits mTORC1 (Heitman et al., 1991; Kim et al., 2002), chronic administration in vivo or in cell culture can inhibit mTORC2 through a mechanism proposed to involve inhibition of complex assembly (Sarbassov et al., 2006; Lamming et al., 2012).
While the psychological effects of large-scale acts of violence most acutely affect those directly involved, there is evidence to suggest that individuals develop similar symptoms– such as post-traumatic stress disorder– without having witnessed first-hand trauma.
These patients are usually acutely admitted, arriving directly from the emergency department, with considerable multimorbidity and polypharmacy, with a high prevalence of infections, dehydration, acute cardiac problems, general medical problems, functional decline and delirium.
Nevertheless, the demonstration of limited growth during chemotherapy could support the hypothesis that GH secretion could be directly and acutely altered by chemotherapeutic agents and that, in acute phases, both ALL and its treatment can caused severe catabolic effects in children, leading to increasing protein breakdown and reducing protein synthesis.
The study lends support to the "microbe-dementia hypothesis" that suggests certain microbes cause long-term damage to the brain in addition to more directly and acutely damaging other organs and bodily tissues.
In harsh and rapidly changing circumstances, Patrise dealt directly with acutely psychotic patients, using all of her interviewing skills and training to assess situations quickly, petition appropriate hospital resources, and describe patients accurately, in clinical terms, so they could receive the best care.
Shortly after, I realized that my way into the story had to be through the lives of people most directly and acutely affected economically by the disaster: the lives of fishermen.
A recent study reported that A-FABP directly and acutely depressed contraction of cardiomyocytes by attenuating intracellular Ca2+ levels [32], suggesting a direct bioactive role of A-FABP may exist in heart function.
