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In addition, it has been reported that the absence of Prnp significantly slows the regeneration process of acutely damaged hind-limb tibialis anterior muscles of mice compared to wild-type muscles, affecting the myogenic precursor cells [29].
Upper and lower respiratory tracts may be acutely damaged after its inhalation (3, 5, 6).
Obviously, these cells cannot be used to replace hepatocytes in acutely damaged livers.
To determine the effect of LAQ on axonal integrity, we analyzed acutely damaged axons characterized by swelling and accumulation of amyloid precursor protein (APP).
Small intestine was chosen for investigation in this study because it is a sensitive organ acutely damaged by hemorrhage [ 3, 4].
In BDNFind−/− mice, there were more axons double-labeled for APP and SMI32 detecting non-phosphorylated neurofilaments that serve as marker for acutely damaged axons (Fig. 2k, l).
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Upregulation of autophagy is generally observed acutely and allows damaged or aggregated proteins to be recycled, reaching a new equilibrium with proteins of better quality by 10 weeks.
It seems likely that even if the L-cells are damaged acutely by the metabolic manifestations of diabetes, reversal of the metabolic abnormalities would be accompanied by restoration of normal GLP-1 secretion, as the previously damaged L-cells would be replaced by a new L-cell population.
Mice were sacrificed 6 h after intra-arterial injections since previous studies established that within 6 h intra-arterially delivered MABs have completed transmigration from the vessel lumen into acutely or chronically damaged skeletal muscle (Galvez et al, 2006; Tedesco et al, 2012).
Here we find MitoSNO to be a highly promising and clinically applicable cardioprotective therapy, which could be applied acutely after an infarct and would protect the heart not only against acute damage but also against long-term injury.
RT-PCR analysis of total RNA revealed an increase of hepatic COX-2 gene expression in acutely as well as "chronically" damaged liver.
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