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MPTP injections were performed according to previously published methods, following the acute schedule.
Eighteen animals received BTZ 0.20 mg/kg as single dose ("acute" schedule) and 22 animals underwent an 8-week period of BTZ administration ("chronic" schedule, 0.20 mg/kg/day three times/week; see [ 28]).
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Euthanasia for tissue harvesting was done under deep xylazine/ketamine anesthesia 1 hour after the single BTZ dose in the "acute" experimental schedule and one day after the last BTZ administration in the "chronic" experimental schedule.
Patients experiencing worsening symptoms were scheduled acute visits with their physician.
The FHU organizational model brought major changes in appointment scheduling, acute care delivery and staff payment system [ 17, 18].
8 9 Patients were included if they were admitted to hospital with ST segment elevation acute coronary syndrome scheduled for primary percutaneous coronary intervention or non-ST segment elevation acute coronary syndrome, with onset of symptoms during the previous 24 hours.
In this regard, results indicate that 7-hydroxy-3,4-dihydrocadalin produced its antinociceptive effect by a glucose levels-independent mechanism as this compound was not able to modify blood glucose in an acute or chronic administration schedule.
In the efficacy and safety study on artemether-lumefantrine (AL) use in children, the co-artemether six-dose schedule, treating acute uncomplicated falciparum malaria achieved rapid parasite clearance and a high cure rate[ 8].
In addition, it is not desirable to subject all patients to the more intense acute reactions of accelerated schedules.
We will include adult patients (≥ 18 years) with a diagnosis of acute coronary heart disease scheduled for CABG (with or without valve surgery).
Physical examination was performed by the research MD at all scheduled and acute visits, including lung and heart stethoscopy and examination of skin 13, ear, nose, and throat.
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