The phrase "acute resolved" is not correct and does not convey a clear meaning in written English.
It may be intended to describe a situation where an acute issue has been resolved, but as it stands, it lacks clarity and context.
Example: "The patient's acute condition was resolved after treatment."
Alternatives: "acute issue addressed" or "acute problem solved".
Immune therapy has emerged as an alternate therapeutic approach for CHB patients because studies have shown that host immunity is either impaired or derailed or distorted or diminished in CHB patients compared to patients with acute resolved hepatitis B who contain the HBV replication and control liver damages.
The combination of positive anti-HBc and anti-HBe raised the concern of acute, resolved or chronic hepatitis B infection.
This would be possible through identification of protective antibody determinants associated with acute resolved infection and by screening methods that specifically enrich/isolate antibodies targeting conserved regions of the viral glycoprotein involved in virus entry.
In this study, we set out to perform a comprehensive assessment of T cell specificity in a large cohort of HCV genotype-3 infected patients with acute, resolved and chronic HCV infection.
One may argue that the most protective antibodies are likely to be present during acute resolved infection (Logvinoff et al., 2004; Osburn et al., 2014; Pestka et al., 2007), yet very little is known about the nature and specificity of these antibody responses.
Hepatitis B screening (Ortho-Clinical Diagnostics VITROS 5600 system Raritan, NJ) performed in anticipation of bone marrow transplantation, 7 days following IVIG therapy showed a positive anti-HBc with a negative HBsAg, raising the possibility of acute, resolved or chronic hepatitis B infection (Table 1).
VCA IgG positivity, however, can be equally attributable to acute, resolving, or remote infections.
Despite the acute, resolving nature of many parvovirus infections, it is now well established that many members of the family Parvoviridae, such as the human erythrovirus B19, can establish lifelong persistence with restricted replication and absence or rarity of detectable long-term viremia (5 – 7 ).
Studies on hepatic gene expression in chimpanzees and humans have revealed intriguing differences between acute resolving and chronic HCV infections [2] [6].
CD4+ T cell help is critical in maintaining antiviral immune responses and such help has been shown to be sustained in acute resolving hepatitis C. In contrast, in evolving chronic hepatitis C CD4+ T cell helper responses appear to be absent or short-lived, using functional assays.
Acute resolving infection is characterized by a rapid decline of viral replication after this peak.
