The phrase "acute repression" is correct and usable in written English.
It can be used in contexts discussing intense or severe forms of suppression, particularly in psychological or sociopolitical discussions.
Example: "The regime's acute repression of dissent led to widespread fear among the population."
Alternatives: "severe suppression" or "intense oppression".
However, the expression of TH is highly regulated, and there is an acute repression of TH phenotype following 6-OHDA injection resulting in maximum loss of nigral TH-immunoreactive neurons at already 2 weeks post-injection [8].
Our data does not support a role for PP2A as the main phosphatase of Maf1 (Oficjalska-Pham et al, 2006), or as a phosphatase needed for acute repression.
Importantly, PP4/Pph3 is needed for acute repression in response to diverse stresses, suggesting that Maf1 and PP4 work together to integrate cell nutrition, stress and integrity.
To examine only resident Maf1 as opposed to newly translated Maf1, cells were pretreated briefly with cycloheximide (CHX; which does not cause either Maf1 dephosphorylation or Pol III repression during acute repression, see below) prior to altering the growth medium.
This rapid translation shut down is akin to the acute translation repression upon cellular stress, and whether it involves the assembly of specific mRNA silencing foci remains to be investigated.
These are likely to become acute if the repression continues.
We observed here that acute induction or repression of synaptic activity by KCl and TTX, respectively, or exposure to the α7-nAChR agonist PNU-282987, had no significant effect on α7-nAChR mobility.
Here, we establish PP4 as the major Maf1 phosphatase complex for acute Pol III repression, identify Pph3 as the involved catalytic subunit, identify the PP4 core and regulatory/interacting proteins involved in Maf1 dephosphorylation, show physical PP4 interaction with Maf1, and reconstitute PP4-dependent Maf1 dephosphorylation in vitro, providing evidence that the effect is direct.
As Pol III specifically interacts with the unphosphorylated form of Maf1, Maf1 dephosphorylation likely impacts the acute establishment phase of repression (Roberts et al, 2006).
Lack of LIP expression resulted in enhanced acute phase response, prolonged repression of cell cycle genes and impaired cell cycle entry of hepatocytes after partial hepatectomy 8.
No significant changes were observed following chronic formoterol administration in the expression of the mRNAs encoding Stat3, Smad1, and Acvr2b, despite significant repression following acute formoterol administration.
