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Studies addressing self-reported quality of life (QoL) in acute mania are scarce and inconsistent.
There is minimal literature on intravenous valproate in treating acute mania.
Patients with acute mania in bipolar disorder require pharmacological treatment to reduce symptoms.
The efficacy of antipsychotics across the initial severity range in patients with acute mania remains unclear.
Several studies have analyzed prescription patterns for bipolar disorder, but few have for acute mania.
Background: Clonazepam and lorazepam are used in the treatment of acute mania but trial results are conflicting.
Methods: Studies were identified by searching MEDLINE and EMBASE for lorazepam or clonazepam in acute mania between 1966 and 2000.
Seven randomized controlled trials were found comparing clonazepam or lorazepam to placebo, haloperidol or lithium in acute mania.
We examined the glutamine/glutamate ratio and levels of other metabolites in acute mania and schizophrenia in this exploratory study.
A sharp increase in BDNF levels was found after treatment of the episode of acute mania (p = 0.010).
These findings suggest that the changes in BDNF serum levels may be associated with treatment response in acute mania.
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