We recently reported the design and synthesis of conformationally restricted analogs (e.g., 2) with improved selectivity for inhibiting invasion versus acute cytotoxicity.
All four patients died; histopathological examination of the kidneys revealed pigmented casts, polymorphonuclear invasion and acute tubular necrosis (ATN).
Human parvovirus B19 may induce aplastic crisis but also acute encephalopathy through direct invasion, although in our case the transient neurological symptoms were rather an effect of hypoxia.
Indeed, many researches have dealt with the acute phase of an invasion (i.e., the period soon after the introduction event), often lacking an adequate temporal context (see review in [ 8]).
Central nervous system (CNS) invasion during acute-stage HIV-infection has been demonstrated in a small number of individuals, but there is no evidence of neurological impairment at this stage and virus infection in brain appears to be controlled until late-stage disease.
- The disruption of established nitrogen cycling by alien plant invasions is acute for species that associate with nitrogen-fixing symbionts, a notion that has been verified by studying invaded habitats, and recovery of altered communities following restoration of sites that were formerly occupied by invasive tree species.
When proteolysis occurs unchecked, then diseases can result, such as Alzheimer's (7), osteoarthritis (8), emphysema (9), tumour invasion (10) and acute pancreatitis (11).
Clinical and experimental research demonstrates that acute disease involves C. jejuni invasion of the cells lining the gastrointestinal tract [ 1- 5].
However, hamster models have provided important insights into the possible mechanisms of the inflammatory response to amebic invasion in the acute phase [ 1, 2].
ANPEP is a well-known marker for acute myeloid leukemia and tumor invasion; it has a regulatory role in angiogenesis [ 78, 79].
