One possible explanation is that microglia only respond to acute interruptions in normal neuronal activity.
In addition, acute interruptions of the cortico-spinal tracts may abolish the spinal reflexes subserved by segments below the lesion ('spinal shock').
During the third week of pacing (days 14 18), acute interruptions in pacing for increasing durations of time (1 5 h sequentially over the 5 days) induced rapid falls (within an hour) in LAP averaging 9.1 ± 0.1 mmHg (P<0.001).
In Alzheimer's patients, lapses in short-term memory are among the first symptoms, while LBD patients might encounter severe disruptions in attention and judgment, hallucinations, delusions and acute sleep interruptions.
Impaired stump healing caused 46 (18%) interruptions and acute medical illness caused 26 (10%); 4 (2%) interruptions were because of other causes.
No severe acute hematologic toxicity requiring interruption of the chemotherapy administration was recorded.
Secondary objectives are rate of therapy stop, rate of therapy interruption, rate of acute toxicity, rate of late toxicity, rate of relapse-free survival, rate of overall-survival and quality of life (EORTC-QLQ30).
Strengths of the study include the use of standardized care protocols, such as ventilation with low tidal volumes in patients with acute lung injury, daily sedation interruption, and spontaneous breathing trials.
Secondary outcome variables are the rate of therapy stop, rate of therapy interruption, rate of acute toxicity, rate of late toxicity, rate of relapse-free survival, rate of overall survival and quality of life (EORTC-QLQ30).
That HPV is still operative in most patients with ARDS is indicated by the clinical observation of acute pulmonary hypertension at accidental interruption of artificial ventilation, and by the hypoxemic effects of intravenously administered vasodilator drugs that inhibit HPV [ 19, 20].
